The U.S. State Department on Saturday issued a worldwide travel alert for Americans abroad, citing heightened tensions in the Middle East and warning that groups supportive of Iran could target U.S. citizens and interests overseas.

The global "Worldwide Caution" alert comes as active fighting between the United States and Iran intensifies. Earlier Saturday, the U.S. military announced that an Iranian missile and drone strike in Jordan killed two American service members and left another missing.

"Due to heightened tensions in the Middle East, the security environment remains complex with the potential for unforeseen escalation," the State Department said in its advisory.

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The agency urged Americans worldwide, particularly those in the Middle East, to exercise increased caution and closely monitor security guidance from local U.S. embassies and consulates.

Risks of Travel Disruptions

While the State Department did not order Americans to evacuate any specific country or implement new restrictions on international travel, officials warned that the conflict could directly impact logistics.

Commercial flight cancellations and periodic airspace closures are expected to cause disruptions across the region as military activity continues. The warning arrives amid mounting uncertainty for commercial airlines and travelers navigating shifting airspace restrictions across the Middle East.

Stakes Rise After Deadly Jordan Attack

The strike in Jordan also injured four additional service members, who have since been treated and discharged from local hospitals, according to military officials.

The latest casualties bring the total number of American military fatalities in the conflict to 16, while more than 420 service members have been wounded.

U.S. Defense Secretary Pete Hegseth paid tribute to the casualties in a post on X, writing: "Godspeed, heroes. Their sacrifice only stiffens our resolve."

Meanwhile, Iran’s Supreme Leader Ayatollah Mojtaba Khamenei issued a defiant statement carried by Iranian state media, warning Washington of severe consequences for escalating the conflict.

"Now that the American enemy is seeking to escalate the conflict thereby incurring even heavier costs and further humiliation, it should know that the noble nation of Iran and the Resistance Front have unforgettable lessons in store for it," Khamenei said.

Conflict Expands Regionally

The diplomatic warning reflects growing anxiety that hostilities are rapidly expanding beyond Iran's borders, threatening to draw neighboring countries deeper into the theater of war.

Hostilities have intensified following the collapse of a month-old ceasefire agreement between Washington and Tehran. Reuters reported that recent Iranian operations appeared to target or affect Saudi Arabia, Kuwait, Bahrain, and Jordan.

Kuwaiti authorities confirmed they intercepted Iranian missiles and drones, while Saudi Arabia’s early warning system issued alerts urging residents in parts of the kingdom to seek shelter. The State Department also said U.S. diplomatic facilities, including outside the Middle East, have been targeted.

The renewed violence follows the failure of a temporary Memorandum of Understanding intended to halt military operations and open negotiations over Iran's nuclear program, sanctions relief, and regional security. Both sides have accused each other of violating the agreement, triggering a swift return to military strikes and targeting of commercial shipping lanes.

Contact Newsweek editors for this story: Anthony Murray.