Poor Sleep Can Age Your Brain By A Year, Study Shows
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In A NutshellSOLNA, Sweden — Tossing and turning at night might be doing more than just leaving you groggy the next morning. A major new study suggests that poor sleep habits could be physically aging your brain, making it appear about a year older than it should be on average.
Researchers analyzed brain scans and sleep patterns from over 27,000 middle-aged and older adults in the UK and found that people with poor sleep habits had brains that looked older than their actual age. Specifically, those with the worst sleep patterns had brains that appeared about one year older than their chronological age on average, while people with moderately poor sleep showed brains that were on average about seven months older.
The study, published in eBioMedicine, used advanced brain imaging and machine learning to estimate “brain age” based on 1,079 different brain features. When someone’s brain age exceeds their actual age, it’s considered an early warning sign that something may be going wrong with brain health.
“Having an older brain age is an early indicator of a departure from optimal brain health,” the researchers wrote. The study fits with earlier findings that poor sleep may be a risk factor for dementia and cognitive decline.
Five Sleep Habits That Protect Your BrainThe research team didn’t just look at one aspect of sleep. Instead, they created a sleep health score based on five key factors:
Only 41% of participants had what researchers classified as healthy sleep, scoring four or five points out of five possible. More than half fell into the intermediate category with two or three healthy sleep characteristics, while about 3% had poor sleep with one or zero healthy habits.
For every single point decrease in the healthy sleep score, the gap between brain age and actual age grew by about half a year. Late chronotype (being a night owl), abnormal sleep duration, and snoring showed the strongest individual associations with older-appearing brains.
Your sleeping patterns are tied to your brain’s “age.” (© Prostock-studio – stock.adobe.com)
Men Show Stronger Brain Aging Effects
The connection between poor sleep and brain aging wasn’t the same for everyone. Men showed a much stronger association than women. Among males, each one-point drop in sleep health was linked to brains that appeared about two and a half months older. For women, the association was weaker and not statistically significant.
Having a genetic risk factor for Alzheimer’s disease didn’t change the sleep-brain aging relationship. Whether someone carried the APOE ε4 gene variant or not, poor sleep was similarly linked to older brain age.
How Inflammation Connects Sleep to Brain AgingOne of the most intriguing aspects involves chronic inflammation, which the body sometimes experiences at low levels over long periods. The researchers measured inflammation using four blood markers: C-reactive protein, white blood cell count, platelet count, and granulocyte-to-lymphocyte ratio.
People with higher inflammation scores showed steeper increases in brain age. More importantly, inflammation appeared to explain about 10% of the link between poor sleep and older-appearing brains. Poor sleep may promote low-grade inflammation throughout the body, which in turn may accelerate brain aging.
Sleep disturbances are known to trigger inflammatory responses, and inflammation has been linked to various forms of brain damage, including problems with blood vessels in the brain, accumulation of abnormal proteins, and neuron loss.
Early Warning Signs Before Symptoms AppearThe study included adults averaging about 55 years old at the start, with brain scans conducted roughly nine years later. All participants were free of dementia, stroke, and other major neurological conditions, meaning the brain age differences emerged before any obvious symptoms appeared.
This timing matters because it suggests poor sleep might contribute to brain aging rather than simply being a consequence of it. While some sleep disturbances occur because of brain degeneration in diseases like Alzheimer’s, this research hints that the relationship can work in the opposite direction too.
Previous research has linked various sleep problems to specific brain changes, including shrinkage, thinning of the brain’s outer layer, reduced hippocampus volume, and deterioration of white matter, which helps different brain regions communicate. Brain age provides a single number that captures many of these changes simultaneously.
The research drew on data from the UK Biobank, a massive health database tracking hundreds of thousands of British adults. While the large sample size provides statistical power, the study population tends to be healthier and more educated than the general UK population, meaning the true associations might be even stronger in the broader public.
Researchers say there are five sleep habits that protect your brain, including getting seven to eight hours of rest a night. (Photo by Andrea Piacquadio from Pexels)
Sleep information came from self-reported questionnaires asking participants about their typical sleep over the past month. People living alone might have been less accurate about whether they snore. The questions also may not have fully captured variations between weekday and weekend sleep, sometimes called “social jetlag,” or differences between working and non-working days that can affect sleep duration and quality.
The study design also means researchers can’t definitively prove that poor sleep causes accelerated brain aging, only that the two are associated. Future studies tracking both sleep and brain changes over time will help clarify whether improving sleep can slow or prevent brain aging.
Nearly 60% of study participants had less-than-healthy sleep patterns, suggesting many people could potentially benefit from better sleep habits. The five components of healthy sleep identified in this study offer specific targets: maintaining an earlier sleep schedule, getting seven to eight hours of sleep, addressing insomnia, dealing with snoring (which can sometimes indicate sleep apnea), and managing daytime sleepiness.
Since the associations appeared even in people under 60 and remained after accounting for factors like physical activity, smoking, alcohol use, and existing health conditions, sleep health appears to matter across different life circumstances. The research adds sleep to the list of potentially modifiable factors that might influence long-term brain health, joining exercise, diet, social engagement, and mental stimulation. Whether actually improving sleep habits can preserve brain structure and prevent cognitive decline remains an important question for future research.
Disclaimer: This article is for general informational purposes only and is not a substitute for professional medical advice. If you are concerned about your sleep or brain health, consult a qualified healthcare provider.
Paper Summary MethodologyThis study analyzed data from 27,500 adults in the UK Biobank (average age 54.7 years, 54% female). Participants completed sleep questionnaires at baseline asking about chronotype (whether they’re morning or evening people), typical sleep duration, insomnia symptoms, snoring, and excessive daytime sleepiness over the past month. Researchers created a healthy sleep score by counting how many of five healthy characteristics each person had: early chronotype, seven to eight hours of daily sleep, no insomnia, no snoring, and no excessive sleepiness. Scores were grouped into healthy (4-5 points), intermediate (2-3 points), and poor (0-1 points) sleep patterns.
About nine years later, participants underwent brain MRI scans using advanced imaging techniques. A machine learning model analyzed 1,079 different brain imaging features across six types of scans to estimate each person’s brain age. Brain age gap was calculated by subtracting chronological age from estimated brain age, with positive numbers indicating an older-appearing brain. Blood samples collected at baseline were used to measure four inflammatory markers (C-reactive protein, white blood cell count, platelet count, and granulocyte-to-lymphocyte ratio) that were combined into an inflammation score.
ResultsPeople with intermediate sleep patterns had brains that appeared 0.62 years older than their chronological age, while those with poor sleep patterns had brains 0.99 years older. For every one-point decrease in healthy sleep score, brain age increased by approximately 0.48 years. Among individual sleep characteristics, late chronotype, abnormal sleep duration, and snoring showed the strongest associations with older brain age.
The association between poor sleep and older brain age was stronger in men than women and appeared consistent across age groups and genetic risk categories. Higher inflammation scores partially explained the sleep-brain age relationship, accounting for about 7% of the intermediate sleep association and 10% of the poor sleep association.
LimitationsThe study population was healthier and more educated than the general UK population, which may limit how well findings apply to other groups. Sleep information relied on self-reports rather than objective measurements like sleep studies, and people living alone may have reported less accurately about snoring. The questions about sleep habits over the past month might not have captured long-term patterns or variations between weekdays and weekends (social jetlag).
The roughly nine-year gap between sleep assessment and brain scans means researchers couldn’t track changes over time or determine whether improving sleep might preserve brain health. The study design shows association but cannot prove that poor sleep directly causes brain aging. Some participants with undiagnosed early-stage brain disease might have had sleep disturbances as a consequence rather than a cause. Finally, about 16% of participants were missing genetic data and 11% were missing inflammation data.
Funding and DisclosuresThe study received funding from Alzheimerfonden, Demensfonden, the Loo and Hans Osterman Foundation for Medical Research, the Knowledge Foundation, and the Swedish Research Council. The authors reported no conflicts of interest. UK Biobank data collection was approved by the UK National Research Ethics Service, and this analysis was approved by the Regional Ethical Review Board in Stockholm.
Publication InformationMiao Y, Wang J, Li X, Guo J, Ekblom MM, Sindi S, Zhang Q, Dove A. “Poor sleep health is associated with older brain age: the role of systemic inflammation.” eBioMedicine, September 30, 2025. Published online ahead of print. DOI: 10.1016/j.ebiom.2025.105941