Intrepid reporter and TV star Dorothy Kilgallen, who investigated the 1963 assassination of President John F. Kennedy, will get a Manhattan street co-named in her honor Saturday on the 60th anniversary of her mysterious death.

Before media icons like Barbara Walters, Kilgallen smashed the glass ceiling in male-dominated NYC newspapers, the New York Evening Journal and New York Journal American. She wrote a syndicated Voice of Broadway column and covered major criminal trials, including the Lindbergh baby kidnapping case and the murder trial of Jack Ruby, who killed JFK assassin Lee Harvey Oswald.

In her heyday, the New York Post called Kilgallen “the most powerful female voice in America.” 

“She never got her due. So many people don’t know who she was,” said City Councilman Robert Holden (D-Queens), who won City Council approval for the street-naming after learning about Kilgallen in books by Mark Shaw, “The Reporter Who Knew Too Much” and “Denial of Justice.”

The corner of Park Avenue and East 68th Street – near a townhouse where the glamorous journalist, mother-of-three and panelist on TV’s What’s My Line? once lived – will be christened “Dorothy Kilgallen Way.”

Speakers at the ceremony include Shaw and Gianni Russo, 81, who played Don Corleone’s wife-beating son-in-law Carlo Rizzi in “The Godfather.” As a teen, Russo worked for Frank Costello, and met Kilgallen among VIPs who gathered at the mobster’s Copacabana nightclub.

“I thought she was the smartest woman in the world,” Russo recalled.

A celebrity in her time, Kilgallen has largely fallen from public memory since her shocking death on Nov. 8,1965.

Witty and charming, she appeared on “What’s My Line?” the night before, guessing the occupation of a mystery guest — a dynamite saleswoman.

In the morning, Kilgallen was found dead in her townhouse –  sitting up in a bed, naked beneath a blue bathrobe, with the same makeup and hair accessory she had worn on TV. 

The city Medical Examiner’s office quickly ruled it accidental – an overdose of sleeping pills and booze. The NYPD shut the case without even taking fingerprints to probe possible foul play, Shaw learned.

But raising questions, Kilgallen’s 18-months of research on the JFK killing – including two exclusive interviews with Jack Ruby –  completely vanished that day, possibly seized by law-enforcement agents. 

Kilgallen, who openly challenged the official “Oswald alone” conclusion, was under surveillance by the FBI. 

Shaw argues that Kilgallen was murdered to stop her efforts to implicate New Orleans Mafia boss Carlos Marcello as mastermind of the JFK and Oswald killings. She told confidants that she would soon break “the biggest story in American history,” and feared for her life. 

Holden has unsuccessfully urged the NYPD’s cold-case unit and Manhattan District Attorney Alvin Bragg to classify Kilgallen’s death as a homicide, even if suspects are no longer alive.

“I’m doing this street-naming not just to celebrate Dorothy’s life, but to make people curious,” Holden said. “Her death needs to be investigated – to finally uncover the truth and to clear her name.”